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Recommended Articles Academic research paper on "Clinical medicine"

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Academic research paper on topic "Recommended Articles"

enriched with mast cells, eosinophils, neutrophils and histiocytes, as well as chromaffin cells, other granule-containing cells. Secretory granules originating from the mast cells in the nodes appear to pass along ductules, two or more of which make up a duct. Our results reveal a potential circulatory system whose anatomical structure and cellular content differ from the blood and lymph systems, and which may be involved in the transport of secretory granules.

Keywords: EMP-3-positive epithelium; granulocytes; intralymphatic nodes and duct

(3) Bioscience Trends, Volume 9, Issue 1, pp. 16-34, 2015

The Advantages of Using Traditional Chinese Medicine as an Adjunctive Therapy in the Whole Course of Cancer Treatment Instead of Only Terminal Stage of Cancer

Fanghua Qi, Lin Zhao, Aiyan Zhou, Bo Zhang, Anyuan Li, Zhixua Wang*, Junqing Han

'Corresponding author's affiliation: Department of Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong University, Ji'nan, China.


Recent studies indicate that Traditional Chinese medicine (TCM) can play an important role in the whole course of cancer treatment such as recovery stages of post-operative, radiotherapy or chemotherapy stages instead of only terminal stage of cancer. In this review, we have summarized current evidence for using TCM as adjuvant cancer treatment in different stages of cancer lesions. Some TCMs (e.g., TJ-41, Liu-jun-zi-tang, PHY906, Coumarin, and Aescine) are capable of improving the post-operative symptoms such as fatigue, pain, appetite, diarrhea, nausea, vomiting, and lymphedema. Some TCMs (e.g., Ginseng, Huang-Qi, BanZhiLian, TJ-48, Huachansu injection, Shenqi fuzheng injection, and Kanglaite injection) in combination with chemo- or radio-therapy are capable of enhancing the efficacy of and diminishing the side effects and complications caused by chemo- and radiotherapy. Taken together, they have great advantages in terms of suppressing tumor progression, relieving surgery complications, increasing the sensitivity of chemo- and radiotherapeutics, improving an organism's immune system function, and lessening the damage caused by surgery, chemo- or radio-therapeutics. They have significant effects on relieving breast cancer-related lymphedema, reducing cancer-related fatigue and pain, improving radiation pneumonitis and gastrointestinal side effects, protecting liver function, and even ameliorating bone marrow suppression. This review of those medicines should contribute to an understanding of Chinese herbal medicines as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer, by providing useful information for development of more effective anti-cancer drugs and making more patients "survival with cancer" for a long time.

Keywords: adjunctive therapy; chemotherapy; post-operation; Radiotherapy; the whole course of cancer treatment; Traditional Chinese medicine (TCM)

(4) Journal of Pharmacopuncture, Vol. 16, No. 4, pp. 36-42, 2013

Shengmaisan Regulates Pacemaker Potentials in Interstitial Cells of Cajal in Mice

Byung Joo Kim*

'Corresponding author's affiliation: Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Korea.


Objectives: Shengmaisan (SMS) is a traditional Chinese medicine prescription widely used for the treatment of diverse organs in Korea. The interstitial cells of Cajal (ICCs) are pacemaker cells that play an important role in the generation of coordinated gastrointestinal (GI) motility. We have aimed to investigate the effects of SMS in the ICCs in the mouse small intestine. Methods: To dissociate the ICCs, we used enzymatic digestions from the small intestine in a mouse. After that, the ICCs were identified immunologically by using the anti-c-kit antibody. In the ICCs, the electrophysiological whole-cell patch-clamp configuration was used to record pacemaker potentials in the cultured ICCs.

Results: The ICCs generated pacemaker potentials in the mouse small intestine. SMS produced membrane depolarization with concentration-dependent manners in the current clamp mode. Pretreatment with a Ca2+ free solution and thapsigargin, a Ca2+-

ATPase inhibitor in the endoplasmic reticulum, stopped the generation of the pacemaker potentials. In the case of Ca2+-free solutions, SMS induced membrane depolarizations. However, when thapsigargin in a bath solution was applied, the membrane depolarization was not produced by SMS. The membrane depolarizations produced by SMS were inhibited by U-73122, an active phospholipase C (PLC) inhibitors. Furthermore, chelerythrine and calphostin C, a protein kinase C (PKC) inhibitors had no effects on SMS-induced membrane depolarizations.

Conclusions: These results suggest that SMS might affect GI motility by modulating the pacemaker activity through an internal Ca2+- and PLC-dependent and PKC-independent pathway in the ICCs.

Keywords: interstitial cells of Cajal; Shengmaisan; traditional Chinese medicine; gastrointestinal motility

(5) Journal of Pharmacopuncture, Vol. 16, No. 4, pp. 43-48, 2013

Bee Venom Pharmacopuncture Responses According to Sasang Constitution and Gender

Chaeweon Kim, Kwangho Lee*

'Corresponding author's affiliation: Department of Acupuncture & Moxibustion Medicine, Sangji University College of Oriental Medicine, Wonju, Korea.


Objectives: The current study was performed to compare the bee venom pharmacopuncture skin test reactions among groups with different sexes and Sasang constitutions.

Methods: Between July 2012 and June 2013, all 76 patients who underwent bee venom pharmacopuncture skin tests and Sasang constitution diagnoses at Oriental Medicine Hospital of Sangji University were included in this study. The skin test was performed on the patient's forearm intracutaneously with 0.05 mL of sweet bee venom (SBV) on their first visit. If the patients showed a positive response, the test was discontinued. On the other hand, if the patient showed a negative response, the test was performed on the opposite forearm intracutaneously with 0.05 mL of bee venom pharmacopuncture 25% on the next day or the next visit. Three groups were made to compare the differences in the bee venom pharmacopuncture skin tests according to sexual difference and Sasang constitution: group A showed a positive response to SBV, group B showed a positive response to bee venom pharmacopuncture 25%, and group C showed a negative response on all bee venom pharmacopuncture skin tests. Fisher's exact test was performed to evaluate the differences statistically.

Results: The results of the bee venom pharmacopuncture skin tests showed no significant differences according to Sasang constitution (p = 0.300) or sexual difference (p = 0.163).

Conclusion: No significant differences on the results of bee venom pharmacopuncture skin tests were observed according to two factors, Sasang constitution and the sexual difference.

Keywords: bee venom; sweet bee venom; skin test; Sasang constitution; sexual difference

(6) Journal of Pharmacopuncture, Vol. 16, No. 4, pp. 49-53, 2013

Sa-am Five-element Acupuncture and Hwangyeon-haedoktang Pharmacopuncture Treatment for an Essential Tremor: Three Case Reports

Jong-Jin Jeong, Seung-Ho Sun*

'Corresponding author's affiliation: Department of Internal Medicine, Sangji University Korean Medicine Hospital, Wonju, Korea.


The purpose of this study was to report the effect of a combination of Sa-am five-element acupuncture and eight-principle pharmacopuncture (EPP) for the treatment of an essential tremor (ET). This study reviewed the medical records treated at OO Korean medical hospital for ET by using diverse types of acupuncture without herbal medicine, other types of physical therapy, and western medication related ET or Parkinson's disease and was performed after the approval of the institutional review board (IRB). The three cases that were finally selected were then extracted and reviewed. The three cases that were finally selected involved three women in their 70s to 80s. The evaluation of the progress was made by using the numeric

rating scale. A combined treatment, the method of liver excess (fîffifê), from among Sa-am five-element acupuncture, and Hwangyeonhaedoktang EPP at CV23 and CV17, was applied to all cases. In all three cases, the ET was improved, and recurred ETs improved with the same treatment. The results suggest that the combined treatment of Sa-am five-element acupuncture and Hwangyeonhaedoktang EPP may be effective for treating an ET, even though this conclusion is based on only three cases.

Keywords: essential tremor; acupuncture; pharmacopuncture; eight-principle pharmacopuncture; Sa-am five-element acupuncture