Scholarly article on topic 'Journal of Pharmacopuncture'

Journal of Pharmacopuncture Academic research paper on "Clinical medicine"

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Academic research paper on topic "Journal of Pharmacopuncture"

Results: In the a (alpha) band, the power values at the Fp1, Fp2, F7, and F8 channels (p < 0.05) during PC7 treatment were significantly decreased. However, the power value at the Fz channel (p < 0.05) during non-acupoint treatment was significantly decreased. In the p (beta) band, the power values at the Fp1 and the Fp2 channels (p < 0.05) during PC7 treatment were significantly decreased. However, the power value at the Fz channel (p < 0.05) during non-acupoint treatment was significantly decreased and those at the F8 and the TCP2 channels (p < 0.05) during non-acupoint treatment were increased. In the 9 (theta) band, the power values at the Fp1, Fp2, F7, and F8 channels (p < 0.05) during PC7 treatment were significantly decreased. But, the power values at the Fz channel (p < 0.05) during non-acupoint treatment was significantly decreased. In the 8 (delta) band, the power values at the Fp1, Fp2, F7, Fz, and F8 channels (p < 0.05) during PC7 treatment were significantly decreased, but the power value at the Fz channel (p < 0.05) during non-acupoint treatment was significantly decreased. The a/p values during PC7 treatment were decreased, as were the p/9 values. Conclusion: These results suggest that acupuncture at PC7 induces decreases in the a (alpha), p (beta), 9 (theta), and 8 (delta) wave values, as well as both the a/p and the p/9 values. Acupuncture at PC7 is thought to affect the activity of the cerebral cortex and the endocrine system. Key Words: Acupuncture, EEG, PC7 (Daereung), Complexity, Power spectrum

(6) Journal of Pharmacopuncture, Vol 13, No. 2, 13-31, 2010

Effect of the Bujeonghangam-tang Extract on Hepatocellular Carcinogenesis and Hepatic Cirrhosis Induced by Diethylnitrosarnine and CCl4 in Rats

Young-Ho Moon, Jin-Hee Won, Goo Moon, Rae-Kyong Heo, Kee-Moon Seung, In-Young Lee, Myung-Joon Jang, So-Yeon Kwon, Deok-Seon Yu

Abstract

Objectives: Bujeonghangam-tang (BH) has been used as a traditional medicine for the treatment of tumors. This study was carried out to clarify the effect of BH extract on hepatocellular carcinogenesis and hepatic cirrhosis induced by diethylnitrosamine (DENA) and CCl4 in rats.

Methods: The experimental groups were divided into two groups, the 8th and the 12th week administration groups, and these were subdivided into four groups: the normal group, cirrhosis- and hepatic-cancer-induced control group, and the groups administered BH extract at 320 mg/kg/day (BHA) and 640 mg/kg/day (BHB), respectively, under the same conditions as the control group.

Results: In the 8th week group; the body weight decreased significantly in the control group compared with the normal group. The activities of transaminase, alkaline phosphatase (ALP), and lactacte dehydrogenase (LDH) were significantly increased (p < 0.05) in the control group compared with the normal group, but were decreased in the BHA and the BHB groups compared with the control group. Alpha fetoprotein (AFP) was increased the most in the control group compared to the BHA and the BHB groups. In the results of light microscopical observation, a number of hepatocytes were damaged in the control group compared with the normal and the BH extract administered groups. The number of hepatic p53 positive cells was reduced in the BH extract administered groups. According to the electron microscopical observation, hepatocarcinoma cells were observed more distinctly in the control group compared with the BH extract administered groups. In the 12 weeks group, the results for the body were similar to those for the 8th week groups. The transaminase and ALT activities were significantly increased (p < 0.05) in the control group compared with the normal group. LDH was significantly (p < 0.05) increased in the control group compared with the normal group but was significantly (p < 0.05) decreased in the BHB group. Alpha fetoprotein (AFP) was increased the most in the control group among the experimental groups. The superoxide dismutase (SOD) activity was significantly (p < 0.05) increased in the control group, but the catalase activity was not increased (p < 0.05) compared with the normal. The number of hepatic p53 positive cells was increased in the control group. The results of electron microscopical observation were similar to those for the 8th week group.

Conclusion: These results suggest that administration of BH extract suppresses or retards DENA- and CCl4-induced

hepatocellular carcinogenesis and hepatic cirrhosis in rats.

Key Words: Bujeonghangam-lang, Hepatocellular carcinogenesis, DENA, CCl4

(7) Journal of Pharmacopuncture, Vol 13, No. 2, 67-73, 2010

Pilot Clinical Study of Hwangryunhaedok-tang Pharmacopunctue Therapy for the Treatment of Post-stroke Depression

Juntae Je, Sangkwan Lee Abstract

Objectives: The purpose of this study is to determine the efficacy and the safety of Hwangryunhaedoktang pharmacopuncture (HHT-PA) therapy as a treatment for post-stroke depression (PSD) in stroke patients.

Methods: Fifteen PSD patients were recruited and were evaluated by using the liver function test (LFT) and the renal function test (RFT) and by using depression scales, the Beck depression inventory (BDI) and the Hamilton depression rating scale (HAM-D), before and after HHT-PA treatment.

Results: The HAM-D score significantly decreased after HHT-PA treatment, regardless of improvement in motor function, but the BDI score did not decrease significantly. All LFT and RFT results were in the normal range before and after HHT-PA treatment.

Conclusion: These results show that HHT-PA decreases PSD symptoms and can be safely used to treat stroke patients, although it has no effect on reducing motor impairment.

Key Words: Hwangryunhaedok-tang pharmacopuncture, Post-stroke depression, HAM-D, BDI

(8) Journal of Pharmacopuncture, Vol 13, No. 2, 93-100, 2010

Effect of Auricular Acupress Therapy on Insomnia of Cancer Patients: Randomized, Single-blinded, Placebo-controlled Trial

In-Sook Jung, Jungsun Kim, Hwa-Seung Yoo Abstract

Background: Auricular acupressure is one of the traditional health care treatments in oriental medicine. Approximately, 30-40% of cancer patients claim to suffer from insomnia, and half of them having chronic and severe insomnia at the same time. Insomnia causes cancer patients to feel more pain, fatigue, depression and anxiety. Objectives: This research was conducted to investigate the efficacy of auricular acupressure for the treatment of cancer patients suffering from insomnia.

Methods: The participants in this study were recruited from the East-West Cancer Center of Daejeon University. Of the patients whose ages ranged from 20 to 75, 12 patients with less than 40 points on Oh's sleeping score (OSS) were recruited. A single-blind, randomized pilot study was performed. The treatment group received auricular acupressure treatment (AAT) on active points, and the control group received a sham acupressure treatment (SAT). In each group, the treatment was administered five times. Sleep parameters were checked by using OSS and the numeric rating scale (NRS). We checked the scale, both before and after every treatment. We analyzed the data statistically by using the independent t-test, paired t-test and the analysis of variance test. (p < 0.05)

Results: Twelve cancer patients participated in this pilot study, and there was no significant difference between the control and the treatment groups. Only 7 of the patients completed the whole treatment process, 4 patients of the AAT group and 3 participants of the SAT group. The OSS of the AAT group increased from 34.0 ± 4.3 to 39.5 ± 3.1, and that of SAT group increased from 38.3 ± 3.5 to 40.0 ± 0.0. There was no significant differences between them. The NRS of the AAT group increased from 6.3 ± 2.9 to 4.8 ± 2.1, and that of the SAT group increased from 7.0 ± 1.0 to 5.0 ± 2.6. No significant difference was observed between them.

Conclusion: Although the two groups showed no significant differences, most of the experimental participants showed increased OSS and NRS after treatments. A large number of participants will be needed in the next study. Key Words: Insomnia, Auricular acupress therapy, Cancer

(9) Journal of Pharmacopuncture, Vol 13, No. 2, 111-120, 2010

Clinical Analysis on 32 Cases of Herniated Lumbar Disc Patients According to Lumbar CT Scan

Jeong-Ho Kim, Jeong-Hwan Lee, Young-Il Kim Abstract

Objectives: This study is to evaluate the effectiveness of oriental medicine for the treatment of lumbar disc herniation.

Methods: A clinical analysis of 32 patients with lumbar disc herniation diagnosed by using a lumbar CT scan was done. Patients admitted to Cheongju Oriental Medicine Hospital from April 2007 to April 2008 were analyzed based on sex, age, the period of disease, condition on admission, the symptoms on admission, admission day, and the treatment efficacy on the day of discharge.

Results & Conclusion: (1) A multiple bulging disc was observed in 37.5% of the CT scans the most common, followed by a single HNP in 28.1% of the CT scans. (2) On the day of discharge almost of the patients showed improvement under VAS 3. (3) The hospital stays were shorter for patients with a single bulging and herniated disc than for patients with a multiple bulging and herniated disc. Key Words: Disc herniation CT scan, Clinical analysis

(10) Journal of Pharmacopuncture, Vol 13, No. 2, 139-143, 2010

Wrist Ganglion Treated with Scolopendrid Pharmacopuncture: Two Case Reports

Min-Seop Shin, Jin-Bok Lee, Beom-yong Song Abstract

Objectives: This study was to investigate the clinical effect of Scolopendrid pharmacopuncture on two patients suffering from wrist ganglion.

Methods: We treated two patients suffering from a wrist ganglion with both acupuncture and injection of Scolopendrid

pharmacopuncture. Then, we measured the sizes of the wrist ganglia and Visual Analogue Scale (VAS).

Results & Conclusion: We found that the sizes of the wrist ganglia of the two patients were significantly reduced

after Scolopendrid pharmacopuncture. Moreover, the pain and the discomfort of the wrists of the patients were

reported to be reduced. Thus, we conclude that Scolopendrid pharmacopuncture has an excellent effect on wrist

ganglion. However, further studies are needed to investigate its exact effects.

Key Words: Wrist ganglion, Scolopendrid, Pharmacopuncture, Korean treatment