Scholarly article on topic 'Erratum to “Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration”'

Erratum to “Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration” Academic research paper on "Veterinary science"

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Academic research paper on topic "Erratum to “Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration”"

Hindawi Publishing Corporation Veterinary Medicine International Volume 2014, Article ID 390875, 2 pages http://dx.doi.org/10.1155/2014/390875

Erratum

Erratum to "Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration"

Mohamed Aboubakr1 and Ahmed Soliman2

1 Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qaliobiya 13736, Egypt

2 Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt

Correspondence should be addressed to Mohamed Aboubakr; mohamedhafez19@yahoo.com Received 23 February 2014; Accepted 2 March 2014; Published 16 March 2014

Copyright © 2014 M. Aboubakr and A. Soliman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The following errors occurred in Table 2 and Page 4.

AUMC value in healthy ducks is 73.46 ^gmL-1 h-2 instead of 37.46 ^g mL- h- .

MAT value in healthy ducks is 0.74 h instead of 0.31 h and MAT value in renal damaged ducks is 0.70 h instead of 2.08 h, with no significance in MAT between healthy and renal damaged ducks.

In Page 4, last line in left column, low MAT (mean absorption time) value is 0.74 h instead of 0.31 h.

2 Veterinary Medicine International

Table 2: Pharmacokinetic parameters of levofloxacin in healthy and renal damaged ducks after a single PO administration of 10 mgkg 1 bwt (n = 6).

Parameter Unit Healthy Renal damaged

^ab h-1 3.31 ±0.10 0.47 ±0.07*"

Kel h-1 0.24 ± 0.02 0.18 ±0.01*

íl/2(ab) h 0.22 ±0.01 1.45 ±0.08***

íl/2(el) h 2.89 ±0.09 3.94 ±0.14***

c ^gmL-1 3.63 ±0.12 4.05 ±0.13

t h 2.05 ±0.08 2.47 ±0.11*

AUC ^gmL-1h-1 17.97 ±2.24 37.38 ± 2.28***

AUMC ^gmL-1h-2 73.46 ±2.61 255.49 ± 17.59**

MRT h 4.08 ±0.14 6.83 ±0.19***

MAT h 0.74 ± 0.08 0.70 ± 0.07

F % 73.56 ± 2.38 71.88 ±2.42

Cmax/MIC Ratio 36.29 ± 2.44 40.52 ± 2.47

AUC/MIC Ratio 179.72 ± 11.35 373.81 ± 21.03**

*P < 0.05, "*p < 0.001 refers to degree of significance.

fcab: first-order absorption rate constant; Kel: elimination rate constant; fi/2(ab): absorption half-life; ii/2(el): elimination half-life; Cmax: maximum plasma

concentration; imax: time to peak plasma concentration; MAT: mean absorption time; F: fraction of drug absorbed systemically after PO administration; Cmax/MIC: maximum serum concentration/minimum inhibitory concentration ratio; AUC/MIC: area under concentration-time curve/MIC ratio.

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