Biological sciences topic list of research papers
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microRNAs of parasitic helminths – Identification, characterization and potential as drug targets
Abstract microRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. They were first identified in the free-living nematode Caenorhabditis elegans, where the miRNAs lin-4 and let-7 were shown to be essential for...
2014 / Collette Britton, Alan D. Winter, Victoria Gillan, Eileen Devaney -
Editorial and Reflection2014 / Robert A Samson
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Ovarian cancer screening—Current status, future directions
Abstract Evidence of a mortality benefit continues to elude ovarian cancer (OC) screening. Data from the US Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial which used a screening strategy incorporating CA125 cut-off and...
2013 / Usha Menon, Michelle Griffin, Aleksandra Gentry-Maharaj -
Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea
Summary Planarians can regenerate any missing body part in a process requiring dividing cells called neoblasts. Historically, neoblasts have largely been considered a homogeneous stem cell population. Most studies, however, analyzed neoblasts at the ...
2014 / M. Lucila Scimone, Kellie M. Kravarik, Sylvain W. Lapan, Peter W. Reddien -
Documentation of the medicinal knowledge of Prosthechea karwinskii in a Mixtec community in Mexico2014 / Gabriela Cruz Garcia, Rodolfo Solano Gomez, Luicita Lagunez Rivera
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Reconstitution of T-cell repertoire after autologous stem cell transplantation: Influence of CD34 selection and cytomegalovirus infection
Abstract The period of immunodeficiency following autologous hematopoietic stem cell transplantation is characterized by transient expansions of CD8+CD45RO+CD57+ T lymphocytes, displaying markers of an activated phenotype. Most evidence suggests...
2005 / Karl S. Peggs, Stephanie Verfuerth, Arnold Pizzey, Naeem Khan, Paul Moss, et al. -
Familial Premature Ovarian Failure in Female Premutated Carriers of Fragile X Syndrome: a Case Report and Literature Review
Summary Objective The fragile X syndrome is the most common form of familial mental retardation. Most males with the FMR1 full mutation function in the mentally retarded range of intelligence. In contrast, females with the FMR1...
2009 / Yu-Shiou Lin, Man-Li Yang -
α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
Summary Accumulation of misfolded alpha-synuclein (α-syn) into Lewy bodies (LBs) and Lewy neurites (LNs) is a major hallmark of Parkinson’s disease (PD) and dementia with LBs (DLB). Recent studies showed that synthetic preformed fibrils (pffs)...
2014 / Hien T. Tran, Charlotte Hiu-Yan Chung, Michiyo Iba, Bin Zhang, John Q. Trojanowski, et al. -
Verbal recognition of infants with cleft lip and palate with and without history of risk indicators for hearing loss2015 / Mariza Ribeiro Feniman, Bárbara Tavares Daniel, Luciana Paula Maximino De Vitto, Isabel Cristina Cavalcanti Lemos, José Roberto Pereira Lauris
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Skin extracellular matrix components accelerate the regenerative potential of Lin− cells2013 / Giedrė Ramanauskaitė, Dovilė Žalalytė, Vytautas Kašėta, Aida Vaitkuvienė, Lilija Kalėdienė, et al.
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From innovation to application: Social–ecological context, diagnostics, drugs and integrated control of schistosomiasis
Abstract Compared to malaria, tuberculosis and HIV/AIDS, schistosomiasis remains a truly neglected tropical disease. Schistosomiasis, perhaps more than any other disease, is entrenched in prevailing social–ecological systems, since transmission is...
2010 / Jürg Utzinger, Eliézer K. N’Goran, Conor R. Caffrey, Jennifer Keiser -
PAS Kinase Drives Lipogenesis through SREBP-1 Maturation
Summary Elevated hepatic synthesis of fatty acids and triglycerides, driven by hyperactivation of the SREBP-1c transcription factor, has been implicated as a causal feature of metabolic syndrome. SREBP-1c activation requires the proteolytic...
2014 / Xiaoying Wu, Donna Romero, Wojciech I. Swiatek, Irene Dorweiler, Chintan K. Kikani, et al. -
PROGRESSION OF ‘OMICS’ METHODOLOGIES FOR UNDERSTANDING THE PATHOGENICITY OF CORYNEBACTERIUM PSEUDOTUBERCULOSIS: THE BRAZILIAN EXPERIENCE
Abstract Since the first successful attempt at sequencing the Corynebacterium pseudotuberculosis genome, large amounts of genomic, transcriptomic and proteomic data have been generated. C. pseudotuberculosis is an interesting bacterium due to its...
2013 / Fernanda A. Dorella, Alfonso Gala-Garcia, Anne C. Pinto, Boutros Sarrouh, Camila A. Antunes, et al. -
PP-039 Determine the new serotype 6C Streptococcus pneumoniae by serological method2009 / Zunjie Liu, Kaihu Yao, Lin Yuan, Wei Gao, Sangjie Yu, et al.
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Costimulatory pathways in transplantation
Abstract Secondary, so-called costimulatory, signals are critically required for the process of T cell activation. Since landmark studies defined that T cells receiving a T cell receptor signal without a costimulatory signal, are tolerized in vitro, ...
2011 / Nina Pilat, Mohamed H. Sayegh, Thomas Wekerle -
Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription
Summary The estrogen receptor α (ERα) controls cell proliferation and tumorigenesis by recruiting various cofactors to estrogen response elements (EREs) to control gene transcription. A deeper understanding of these transcriptional mechanisms may...
2014 / Sankari Nagarajan, Tareq Hossan, Malik Alawi, Zeynab Najafova, Daniela Indenbirken, et al. -
Light- and electron-microscopic studies of olfactory organ of Red-tail shark, Epalzeorhynchos bicolor (Teleostei: Cyprinidae)
Abstract Olfaction plays a major role in various life activities of fish. The present study describes for the first time the gross morphology, histology, histochemistry, surface architecture and ultrastructure of the olfactory epithelium of Red-tail ...
2014 / Doaa M. Mokhtar, Hanan H. Abd-Elhafeez -
139 Candidaemia in the Australian Intensive Care Unit: Epidemiology, clinical features and outcome from a 3 year nationwide study2006 / D. Marriott, E.G. Playford, Q. Nguyen, S. Chen, D. Ellis, et al.
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Index volume 12004 /
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Microarray-based optimization to detect genomic deletion mutations
Abstract We performed array comparative genome hybridization (aCGH) analyses of five Arabidopsis thaliana mutants with genomic deletions ranging in size from 4bp to >5kb. We used the Roche NimbleGen Arabidopsis CGH 3×720 K whole genome custom...
2014 / Eric J. Belfield, Carly Brown, Xiangchao Gan, Caifu Jiang, Dilair Baban, et al.