Biological sciences topic list of research papers
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Construction of the third generation Zea mays haplotype map2017 / Robert Bukowski, Xiaosen Guo, Yanli Lu, Cheng Zou, Bing He, et al.
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NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium
Abstract Valvular and vascular calcification are common causes of cardiovascular morbidity and mortality. Developing effective treatments requires understanding the molecular underpinnings of these processes. Shear stress is thought to play a role...
2015 / Mark P. White, Christina V. Theodoris, Lei Liu, William J. Collins, Kathleen W. Blue, et al. -
Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury
Abstract Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and in the induction of corticosteroid (CS) insensitivity. Chronic ozone exposure leads to a model of COPD with lung inflammation...
2014 / Mariona Pinart, Farhana Hussain, Sima Shirali, Feng Li, Jie Zhu, et al. -
Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest
Summary Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown. Here, we show...
2015 / Dina Dikovskaya, John J. Cole, Susan M. Mason, Colin Nixon, Saadia A. Karim, et al. -
Active autophagy but not lipophagy in macrophages with defective lipolysis
Abstract During autophagy, autophagosomes fuse with lysosomes to degrade damaged organelles and misfolded proteins. Breakdown products are released into the cytosol and contribute to energy and metabolic building block supply, especially during...
2015 / Madeleine Goeritzer, Nemanja Vujic, Stefanie Schlager, Prakash G. Chandak, Melanie Korbelius, et al. -
Farmer seed networks make a limited contribution to agriculture? Four common misconceptions
Abstract The importance of seed provisioning in food security and nutrition, agricultural development and rural livelihoods, and agrobiodiversity and germplasm conservation is well accepted by policy makers, practitioners and researchers. The role...
2015 / Oliver T. Coomes, Shawn J. McGuire, Eric Garine, Sophie Caillon, Doyle McKey, et al. -
RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs2017 / Jackson B. Trotman, Andrew J. Giltmier, Chandrama Mukherjee, Daniel R. Schoenberg
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Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes
Abstract Objective Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators...
2015 / Samantha E. Adamson, Akshaya K. Meher, Yu-hsin Chiu, Joanna K. Sandilos, Nathaniel P. Oberholtzer, et al. -
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome
Summary Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues. In controlled ADAR expression...
2015 / Debora Fumagalli, David Gacquer, Françoise Rothé, Anne Lefort, Frederick Libert, et al. -
Quantitative proteomics and transcriptomics reveals metabolic differences in attracting and non-attracting human-in-mouse glioma stem cell xenografts and stromal cells
Abstract Bone marrow-derived human mesenchymal stem cells (BM-hMSCs) show promise as cell-based delivery vehicles for anti-glioma therapeutics, due to innate tropism for gliomas. However, in clinically relevant human-in-mouse glioma stem cell...
2015 / Norelle C. Wildburger, Cheryl F. Lichti, Richard D. LeDuc, Mary Schmidt, Roger A. Kroes, et al. -
Elevated CO2-Induced Responses in Stomata Require ABA and ABA Signaling
Summary An integral part of global environment change is an increase in the atmospheric concentration of CO2 ([CO2]) [1]. Increased [CO2] reduces leaf stomatal apertures and density of stomata that plays out as reductions in evapotranspiration...
2015 / Caspar Chater, Kai Peng, Mahsa Movahedi, Jessica A. Dunn, Heather J. Walker, et al. -
Analysis of a Genetic Polymorphism in the Costimulatory Molecule TNFSF4 with Hematopoietic Stem Cell Transplant Outcomes
Abstract Despite stringent procedures to secure the best HLA matching between donors and recipients, life-threatening complications continue to occur after hematopoietic stem cell transplantation (HSCT). Studying single nucleotide polymorphism (SNP) ...
2015 / Peter T. Jindra, Susan E. Conway, Stacy M. Ricklefs, Stephen F. Porcella, Sarah L. Anzick, et al. -
Generation of Functional Dopaminergic Neurons from Reprogramming Fibroblasts by Nonviral-based Mesoporous Silica Nanoparticles2018 / Jen-Hsuan Chang, Ping-Hsing Tsai, Kai-Yi Wang, Yu-Ting Wei, Shih-Hwa Chiou, et al.
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Mutations in KPTN Cause Macrocephaly, Neurodevelopmental Delay, and Seizures
The proper development of neuronal circuits during neuromorphogenesis and neuronal-network formation is critically dependent on a coordinated and intricate series of molecular and cellular cues and responses. Although the cortical actin cytoskeleton is known to...
2013 / Emma L. Baple, Reza Maroofian, Barry A. Chioza, Maryam Izadi, Harold E. Cross, et al. -
A novel dual promoter DNA vaccine induces CD8+ response against Toxoplasma gondii sporozoite specific surface protein “SporoSAG” through non-apoptotic cells
Abstract Toxoplasma gondii is a protozoan parasite that can infect all warm blooded animals including humans. During natural course of T. gondii infection, bradyzoites or sporozoites invade the intestinal cells and turn into...
2014 / Sultan Gülçe İz, Mert Döşkaya, Ayşe Caner, Aysu Değirmenci Döşkaya, Fernando Rodriguez, et al. -
Uncertainties associated with assessing the public health risk from Legionella2014 / Harriet Whiley
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Transcriptome changes induced by arbuscular mycorrhizal fungi in sunflower (Helianthus annuus L.) roots2018 / Alberto Vangelisti, Lucia Natali, Rodolfo Bernardi, Cristiana Sbrana, Alessandra Turrini, et al.
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Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection
Abstract Hepatitis C virus (HCV) infection facilitates the development of hepatocellular carcinoma (HCC). Activation of Ras/Raf/MEK/ERK pathway is found in more than 30% human cancers. Here, we revealed a novel mechanism underlying the regulation of ...
2015 / Qi Zhang, Liang Wei, Hongchuan Yang, Wanqi Yang, Qingyu Yang, et al. -
Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster C ultured Cells2017 / Stephanie E. Mohr, Kirstin Rudd, Yanhui Hu, Wei R. Song, Quentin Gilly, et al.
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Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing
Abstract Due to the increasing age of our society and a rise in engagement of young people in extreme and/or competitive sports, both tendinopathies and tendon ruptures present a clinical and financial challenge. Tendon has limited natural healing...
2017 / Magdalena Schneider, Peter Angele, Tero A.H. Järvinen, Denitsa Docheva