Biological sciences topic list of research papers
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Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia
Summary AMPK is a master regulator of cellular metabolism that exerts either oncogenic or tumor suppressor activity depending on context. Here, we report that the specific AMPK agonist GSK621 selectively kills acute myeloid leukemia (AML) cells but...
2015 / Pierre Sujobert, Laury Poulain, Etienne Paubelle, Florence Zylbersztejn, Adrien Grenier, et al. -
Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects2016 / Hamid R. Molavian, Aaron Goldman, Colin J. Phipps, Mohammad Kohandel, Bradly G. Wouters, et al.
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Chronic exposure to cobalt compounds — an in vivo study2014 / Yordanka Gluhcheva, Vasil Atanasov, Juliana Ivanova, Ekaterina Pavlova
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Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers
Abstract Eluxadoline, an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist developed for the treatment of diarrhea-predominant irritable bowel syndrome, normalizes gastrointestinal (GI) transit and defecation...
2014 / Wakako Fujita, Ivone Gomes, Leonard S. Dove, David Prohaska, Gail McIntyre, et al. -
Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses2014 / Derek S. Borgwardt, Aaron D. Martin, Jonathan R. Van Hemert, Jianyi Yang, Carol L. Fischer, et al.
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Six Weeks of Core Stability Training Improves Landing Kinetics Among Female Capoeira Athletes: A Pilot Study2015 / Simone Araujo, Daniel Cohen, Lawrence Hayes
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Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection
Abstract CRISPR-Cas9 systems provide a platform for high efficiency genome editing that are enabling innovative applications of mammalian cell engineering. However, the delivery of Cas9 and synthesis of guide RNA (gRNA) remain as steps that can...
2015 / Xiquan Liang, Jason Potter, Shantanu Kumar, Yanfei Zou, Rene Quintanilla, et al. -
Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain
Abstract Glutamate, the main excitatory neurotransmitter in the central nervous system, exerts its effect through ionotropic and metabotropic receptors. Of these, group III mGlu receptors (mGlu 4, 6, 7, 8) are among the least studied due to a lack...
2015 / Rachel D. Moloney, Anna V. Golubeva, Richard M. O'Connor, Mikhail Kalinichev, Timothy G. Dinan, et al. -
XTACC3–XMAP215 association reveals an asymmetric interaction promoting microtubule elongation2014 / Gulnahar B. Mortuza, Tommaso Cavazza, Maria Flor Garcia-Mayoral, Dario Hermida, Isabel Peset, et al.
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The Centre for Development and Environment (CDE), University of Berne2006 / Hans Hurni, Andreas Kläy, Thomas Kohler, Urs Wiesmann
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A Global Overview of Mountain Protected Areas on the World Heritage List2006 / Jim Thorsell
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Tasimelteon: A selective and unique receptor binding profile
Abstract Hetlioz® (tasimelteon) is the first approved treatment in the United States for Non-24-Hour Sleep-Wake Disorder (Non-24). We present here data on the in vitro binding affinity of tasimelteon for both human melatonin receptors MT1 and MT2,...
2014 / Christian Lavedan, Mark Forsberg, Anthony J. Gentile -
Extensive rewiring of epithelial-stromal co-expression networks in breast cancer2015 / Eun-Yeong Oh, Stephen M Christensen, Sindhu Ghanta, Jong Cheol Jeong, Octavian Bucur, et al.
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Repression of GAD Autoantigen Expression in Pancreas β-Cells by Delivery of Antisense Plasmid/PEG-g-PLL Complex2002 / M Lee
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Trace elements content in the selected medicinal plants traditionally used for curing skin diseases by the natives of Mizoram, India
Abstract Objective To determine the trace elements content in the selected medicinal plants, namely, Eryngium foetidum L., Mimosa pudica L., Polygonum plebeium, and Prunus cerasoides D. Don traditionally used by the natives of the...
2014 / Jay Prakash Rajan, Kshetrimayum Birla Singh, Sanjiv Kumar, Raj Kumar Mishra -
Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory2015 / Torben J. Hausrat, Mary Muhia, Kimberly Gerrow, Philip Thomas, Wiebke Hirdes, et al.
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Characterization and expression of the cytochrome P450 gene family in diamondback moth, Plutella xylostella (L.)2015 / Liying Yu, Weiqi Tang, Weiyi He, Xiaoli Ma, Liette Vasseur, et al.
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Hypothesis: Cryptochromes and Brown Fat are Essential for Adaptation and Affect Mood and Mood-Related Behaviors2012 / Timo Partonen
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Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice2014 / G. B. Rogers, J. Kozlowska, J. Keeble, K. Metcalfe, M. Fao, et al.
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leeHom: adaptor trimming and merging for Illumina sequencing reads2014 / G. Renaud, U. Stenzel, J. Kelso